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The below Stat Priority recommendation is based on a mix of SimulationCraft, spreadsheets, in-game testing and through collaboration with other players. Understanding the priority will help you make decisions on which gear to use and how to optimize it, helping improve your overall tanking performance.

Strength increases your attack power and the damage dealt by your abilities. Further, Strength slightly increases your chance to Parry.

Haste increases attack and spell casting speed, adds additional damage and healing to DoTs A spell or ability that does damage over time. and HoTs A spell or ability that heals over time. , and reduces the GCD A universal cooldown activated by most abilities. . Also, Haste increases your Rune regeneration speed. As Blood, Haste allows for more frequent use of your Rune-based threat and survivability abilities.

Mastery provides a passive bonus to your character based on your specialization. Mastery Blood Shield provides an absorption shield with every Death Strike .

Critical Strike increase the chance for your spells and attacks to critically hit for additional damage and healing. As Blood, Crit also increases your chance to Parry via Riposte .

The below Stat Priority recommendation is based on a mix of SimulationCraft, spreadsheets, in-game testing and through collaboration with other players. Understanding the priority will help you make decisions on which gear to use and how to optimize it, helping improve your overall tanking performance.

Strength increases your attack power and the damage dealt by your abilities. Further, Strength slightly increases your chance to Parry.

Haste increases attack and spell casting speed, adds additional damage and healing to DoTs A spell or ability that does damage over time. and HoTs A spell or ability that heals over time. , and reduces the GCD A universal cooldown activated by most abilities. . Also, Haste increases your Rune regeneration speed. As Blood, Haste allows for more frequent use of your Rune-based threat and survivability abilities.

Mastery provides a passive bonus to your character based on your specialization. Mastery Blood Shield provides an absorption shield with every Death Strike .

Critical Strike increase the chance for your spells and attacks to critically hit for additional damage and healing. As Blood, Crit also increases your chance to Parry via Riposte .

Graft-versus-host-disease (GVHD) is a complication of allogeneic stem cell transplantation in which lymphocytes from the donor stem cells see the recipient's cells as foreign.  As a result, these lymphocytes react against the tissues of the patient causing GVHD.  GVHD manifests particularly in the skin, liver, and gastrointestinal tract.

GVHD may manifest itself in a variety of ways and range from mild to severe.  Mild GVHD may appear as a minor skin rash treatable with steroids.  Mild reactions are usually a sign of better outcome because it can be evidence that graft-versus-leukemia if taking effect.   Graft-versus-leukemia effect means that the donor's cells are attacking the patient's leukemia cells and helping to erradicate the leukemia.

In severe GVHD, more aggressive therapy must be done.  If your physician recommends that you have aggressive therapy to combat GVHD, discuss the ramifications and duration so that you can understand the consequences.

Yes.  The recipients blood type eventually changes to the donor type.  That means if you had a blood type of A+ prior to transplant and your donor had a blood type of O, eventually your blood type would become O.  I may take several weeks, possibly months for your original blood type to disappear, but eventually it will.  

Although this has happened before, it is extremely rare and is not considered a major factor in the decision process for undergoing a transplant.  Since there is usually only one suitable donor, the benefit of the transplant far outweighs the risk of contracting an allergy.

Acute GVHD usually develops in the first 100 days following a transplant. Thus, you will see many transplant patients remain either hospitalized or staying in close proximity to their transplant center.  Acute GVHD may include the skin, liver, and gastrointestinal tract and primarily lead to skin rash, jaundice, and diarrhea.  Chronic GVHD is more subtle and may include the eyes or mouth becoming dry, a rash in the mouth, thickening or tightening of the skin, as well as chronic liver issues. 

Cancer is a process of uncontrolled abnormal cell growth and development. Under normal circumstances, cells are formed, mature, carry out their intended function, and then die. New cells are constantly regenerated in the body to replace those cells and to maintain normal cellular function.

Cells may grow and reproduce in a disorganized and out-of-control fashion. Cells may fail to develop properly, so they will not function normally. Cells may fail to die normally. One or a combination of these processes may occur when cells become cancerous.

Leukemia is a cancer of blood-forming cells in the bone marrow. These deranged, immature cells accumulate in the blood and within organs of the body. They are not able to carry out the normal functions of blood cells.

Normal blood contains white blood cells, red blood cells, and platelets. All three types of blood elements develop from one immature cell type, called blood/marrow stem cells, in a process called hematopoiesis.

The first step in the process of stem cell maturation is differentiation into two groups: the myeloid stem cell line and the lymphoid stem cell line.

Leukemia of all forms is presently estimated to be diagnosed in about 54,000 people in the U.S. in 2015 (ACS - Facts and Figures 2015).

Chronic myelogenous leukemia ( CML ) is a cancer of the white blood cells . It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes ( neutrophils , eosinophils and basophils ) and their precursors is found. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome .

CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatic improved long-term survival rates since 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs. In Western countries, CML accounts for 15–25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common). [3]

The way CML presents depends on the stage of the disease at diagnosis as it has been known to skip stages in some cases. [4]

Most patients (~90%) are diagnosed during the chronic stage which is most often asymptomatic. In these cases it may be diagnosed incidentally with an elevated white blood cell count on a routine laboratory test. It can also present with symptoms indicative of hepatosplenomegaly and the resulting upper quadrant pain this causes. The enlarged spleen may put pressure on the stomach causing a loss of appetite and resulting weight loss. It may also present with mild fever and night sweats due to an elevated basal level of metabolism. [4]

Some (<10%) are diagnosed during the accelerated stage which most often presents bleeding, petechiae and ecchymosis . [4] In these patients fevers are most commonly the result of opportunistic infections. [4]

Some patients are initially diagnosed in the blast phase in which the symptoms are most likely fever, bone pain and an increase in bone marrow fibrosis. [4]

The below Stat Priority recommendation is based on a mix of SimulationCraft, spreadsheets, in-game testing and through collaboration with other players. Understanding the priority will help you make decisions on which gear to use and how to optimize it, helping improve your overall tanking performance.

Strength increases your attack power and the damage dealt by your abilities. Further, Strength slightly increases your chance to Parry.

Haste increases attack and spell casting speed, adds additional damage and healing to DoTs A spell or ability that does damage over time. and HoTs A spell or ability that heals over time. , and reduces the GCD A universal cooldown activated by most abilities. . Also, Haste increases your Rune regeneration speed. As Blood, Haste allows for more frequent use of your Rune-based threat and survivability abilities.

Mastery provides a passive bonus to your character based on your specialization. Mastery Blood Shield provides an absorption shield with every Death Strike .

Critical Strike increase the chance for your spells and attacks to critically hit for additional damage and healing. As Blood, Crit also increases your chance to Parry via Riposte .

Graft-versus-host-disease (GVHD) is a complication of allogeneic stem cell transplantation in which lymphocytes from the donor stem cells see the recipient's cells as foreign.  As a result, these lymphocytes react against the tissues of the patient causing GVHD.  GVHD manifests particularly in the skin, liver, and gastrointestinal tract.

GVHD may manifest itself in a variety of ways and range from mild to severe.  Mild GVHD may appear as a minor skin rash treatable with steroids.  Mild reactions are usually a sign of better outcome because it can be evidence that graft-versus-leukemia if taking effect.   Graft-versus-leukemia effect means that the donor's cells are attacking the patient's leukemia cells and helping to erradicate the leukemia.

In severe GVHD, more aggressive therapy must be done.  If your physician recommends that you have aggressive therapy to combat GVHD, discuss the ramifications and duration so that you can understand the consequences.

Yes.  The recipients blood type eventually changes to the donor type.  That means if you had a blood type of A+ prior to transplant and your donor had a blood type of O, eventually your blood type would become O.  I may take several weeks, possibly months for your original blood type to disappear, but eventually it will.  

Although this has happened before, it is extremely rare and is not considered a major factor in the decision process for undergoing a transplant.  Since there is usually only one suitable donor, the benefit of the transplant far outweighs the risk of contracting an allergy.

Acute GVHD usually develops in the first 100 days following a transplant. Thus, you will see many transplant patients remain either hospitalized or staying in close proximity to their transplant center.  Acute GVHD may include the skin, liver, and gastrointestinal tract and primarily lead to skin rash, jaundice, and diarrhea.  Chronic GVHD is more subtle and may include the eyes or mouth becoming dry, a rash in the mouth, thickening or tightening of the skin, as well as chronic liver issues. 

The below Stat Priority recommendation is based on a mix of SimulationCraft, spreadsheets, in-game testing and through collaboration with other players. Understanding the priority will help you make decisions on which gear to use and how to optimize it, helping improve your overall tanking performance.

Strength increases your attack power and the damage dealt by your abilities. Further, Strength slightly increases your chance to Parry.

Haste increases attack and spell casting speed, adds additional damage and healing to DoTs A spell or ability that does damage over time. and HoTs A spell or ability that heals over time. , and reduces the GCD A universal cooldown activated by most abilities. . Also, Haste increases your Rune regeneration speed. As Blood, Haste allows for more frequent use of your Rune-based threat and survivability abilities.

Mastery provides a passive bonus to your character based on your specialization. Mastery Blood Shield provides an absorption shield with every Death Strike .

Critical Strike increase the chance for your spells and attacks to critically hit for additional damage and healing. As Blood, Crit also increases your chance to Parry via Riposte .

Graft-versus-host-disease (GVHD) is a complication of allogeneic stem cell transplantation in which lymphocytes from the donor stem cells see the recipient's cells as foreign.  As a result, these lymphocytes react against the tissues of the patient causing GVHD.  GVHD manifests particularly in the skin, liver, and gastrointestinal tract.

GVHD may manifest itself in a variety of ways and range from mild to severe.  Mild GVHD may appear as a minor skin rash treatable with steroids.  Mild reactions are usually a sign of better outcome because it can be evidence that graft-versus-leukemia if taking effect.   Graft-versus-leukemia effect means that the donor's cells are attacking the patient's leukemia cells and helping to erradicate the leukemia.

In severe GVHD, more aggressive therapy must be done.  If your physician recommends that you have aggressive therapy to combat GVHD, discuss the ramifications and duration so that you can understand the consequences.

Yes.  The recipients blood type eventually changes to the donor type.  That means if you had a blood type of A+ prior to transplant and your donor had a blood type of O, eventually your blood type would become O.  I may take several weeks, possibly months for your original blood type to disappear, but eventually it will.  

Although this has happened before, it is extremely rare and is not considered a major factor in the decision process for undergoing a transplant.  Since there is usually only one suitable donor, the benefit of the transplant far outweighs the risk of contracting an allergy.

Acute GVHD usually develops in the first 100 days following a transplant. Thus, you will see many transplant patients remain either hospitalized or staying in close proximity to their transplant center.  Acute GVHD may include the skin, liver, and gastrointestinal tract and primarily lead to skin rash, jaundice, and diarrhea.  Chronic GVHD is more subtle and may include the eyes or mouth becoming dry, a rash in the mouth, thickening or tightening of the skin, as well as chronic liver issues. 

Cancer is a process of uncontrolled abnormal cell growth and development. Under normal circumstances, cells are formed, mature, carry out their intended function, and then die. New cells are constantly regenerated in the body to replace those cells and to maintain normal cellular function.

Cells may grow and reproduce in a disorganized and out-of-control fashion. Cells may fail to develop properly, so they will not function normally. Cells may fail to die normally. One or a combination of these processes may occur when cells become cancerous.

Leukemia is a cancer of blood-forming cells in the bone marrow. These deranged, immature cells accumulate in the blood and within organs of the body. They are not able to carry out the normal functions of blood cells.

Normal blood contains white blood cells, red blood cells, and platelets. All three types of blood elements develop from one immature cell type, called blood/marrow stem cells, in a process called hematopoiesis.

The first step in the process of stem cell maturation is differentiation into two groups: the myeloid stem cell line and the lymphoid stem cell line.

Leukemia of all forms is presently estimated to be diagnosed in about 54,000 people in the U.S. in 2015 (ACS - Facts and Figures 2015).

Chronic myelogenous leukemia ( CML ) is a cancer of the white blood cells . It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes ( neutrophils , eosinophils and basophils ) and their precursors is found. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome .

CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatic improved long-term survival rates since 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs. In Western countries, CML accounts for 15–25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common). [3]

The way CML presents depends on the stage of the disease at diagnosis as it has been known to skip stages in some cases. [4]

Most patients (~90%) are diagnosed during the chronic stage which is most often asymptomatic. In these cases it may be diagnosed incidentally with an elevated white blood cell count on a routine laboratory test. It can also present with symptoms indicative of hepatosplenomegaly and the resulting upper quadrant pain this causes. The enlarged spleen may put pressure on the stomach causing a loss of appetite and resulting weight loss. It may also present with mild fever and night sweats due to an elevated basal level of metabolism. [4]

Some (<10%) are diagnosed during the accelerated stage which most often presents bleeding, petechiae and ecchymosis . [4] In these patients fevers are most commonly the result of opportunistic infections. [4]

Some patients are initially diagnosed in the blast phase in which the symptoms are most likely fever, bone pain and an increase in bone marrow fibrosis. [4]

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The below Stat Priority recommendation is based on a mix of SimulationCraft, spreadsheets, in-game testing and through collaboration with other players. Understanding the priority will help you make decisions on which gear to use and how to optimize it, helping improve your overall tanking performance.

Strength increases your attack power and the damage dealt by your abilities. Further, Strength slightly increases your chance to Parry.

Haste increases attack and spell casting speed, adds additional damage and healing to DoTs A spell or ability that does damage over time. and HoTs A spell or ability that heals over time. , and reduces the GCD A universal cooldown activated by most abilities. . Also, Haste increases your Rune regeneration speed. As Blood, Haste allows for more frequent use of your Rune-based threat and survivability abilities.

Mastery provides a passive bonus to your character based on your specialization. Mastery Blood Shield provides an absorption shield with every Death Strike .

Critical Strike increase the chance for your spells and attacks to critically hit for additional damage and healing. As Blood, Crit also increases your chance to Parry via Riposte .

Graft-versus-host-disease (GVHD) is a complication of allogeneic stem cell transplantation in which lymphocytes from the donor stem cells see the recipient's cells as foreign.  As a result, these lymphocytes react against the tissues of the patient causing GVHD.  GVHD manifests particularly in the skin, liver, and gastrointestinal tract.

GVHD may manifest itself in a variety of ways and range from mild to severe.  Mild GVHD may appear as a minor skin rash treatable with steroids.  Mild reactions are usually a sign of better outcome because it can be evidence that graft-versus-leukemia if taking effect.   Graft-versus-leukemia effect means that the donor's cells are attacking the patient's leukemia cells and helping to erradicate the leukemia.

In severe GVHD, more aggressive therapy must be done.  If your physician recommends that you have aggressive therapy to combat GVHD, discuss the ramifications and duration so that you can understand the consequences.

Yes.  The recipients blood type eventually changes to the donor type.  That means if you had a blood type of A+ prior to transplant and your donor had a blood type of O, eventually your blood type would become O.  I may take several weeks, possibly months for your original blood type to disappear, but eventually it will.  

Although this has happened before, it is extremely rare and is not considered a major factor in the decision process for undergoing a transplant.  Since there is usually only one suitable donor, the benefit of the transplant far outweighs the risk of contracting an allergy.

Acute GVHD usually develops in the first 100 days following a transplant. Thus, you will see many transplant patients remain either hospitalized or staying in close proximity to their transplant center.  Acute GVHD may include the skin, liver, and gastrointestinal tract and primarily lead to skin rash, jaundice, and diarrhea.  Chronic GVHD is more subtle and may include the eyes or mouth becoming dry, a rash in the mouth, thickening or tightening of the skin, as well as chronic liver issues. 

Cancer is a process of uncontrolled abnormal cell growth and development. Under normal circumstances, cells are formed, mature, carry out their intended function, and then die. New cells are constantly regenerated in the body to replace those cells and to maintain normal cellular function.

Cells may grow and reproduce in a disorganized and out-of-control fashion. Cells may fail to develop properly, so they will not function normally. Cells may fail to die normally. One or a combination of these processes may occur when cells become cancerous.

Leukemia is a cancer of blood-forming cells in the bone marrow. These deranged, immature cells accumulate in the blood and within organs of the body. They are not able to carry out the normal functions of blood cells.

Normal blood contains white blood cells, red blood cells, and platelets. All three types of blood elements develop from one immature cell type, called blood/marrow stem cells, in a process called hematopoiesis.

The first step in the process of stem cell maturation is differentiation into two groups: the myeloid stem cell line and the lymphoid stem cell line.

Leukemia of all forms is presently estimated to be diagnosed in about 54,000 people in the U.S. in 2015 (ACS - Facts and Figures 2015).


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